Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2
Identifieur interne : 000489 ( Main/Exploration ); précédent : 000488; suivant : 000490Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2
Auteurs : Orsolya Farkas [Hongrie] ; Orsolya Pal Cz [Hongrie] ; Erzsébet Pászti-Gere [Hongrie] ; Péter Gálfi [Hongrie]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2015.
Abstract
The
Url:
DOI: 10.1155/2015/673847
PubMed: 26180592
PubMed Central: 4477253
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2</title><author><name sortKey="Farkas, Orsolya" sort="Farkas, Orsolya" uniqKey="Farkas O" first="Orsolya" last="Farkas">Orsolya Farkas</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Pal Cz, Orsolya" sort="Pal Cz, Orsolya" uniqKey="Pal Cz O" first="Orsolya" last="Pal Cz">Orsolya Pal Cz</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Paszti Gere, Erzsebet" sort="Paszti Gere, Erzsebet" uniqKey="Paszti Gere E" first="Erzsébet" last="Pászti-Gere">Erzsébet Pászti-Gere</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Galfi, Peter" sort="Galfi, Peter" uniqKey="Galfi P" first="Péter" last="Gálfi">Péter Gálfi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26180592</idno><idno type="pmc">4477253</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477253</idno><idno type="RBID">PMC:4477253</idno><idno type="doi">10.1155/2015/673847</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000123</idno><idno type="wicri:Area/Pmc/Curation">000123</idno><idno type="wicri:Area/Pmc/Checkpoint">000380</idno><idno type="wicri:Area/Ncbi/Merge">001C20</idno><idno type="wicri:Area/Ncbi/Curation">001C20</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C20</idno><idno type="wicri:doubleKey">1942-0900:2015:Farkas O:polymethoxyflavone:apigenin:trimethylether</idno><idno type="wicri:Area/Main/Merge">000489</idno><idno type="wicri:Area/Main/Curation">000489</idno><idno type="wicri:Area/Main/Exploration">000489</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2</title><author><name sortKey="Farkas, Orsolya" sort="Farkas, Orsolya" uniqKey="Farkas O" first="Orsolya" last="Farkas">Orsolya Farkas</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Pal Cz, Orsolya" sort="Pal Cz, Orsolya" uniqKey="Pal Cz O" first="Orsolya" last="Pal Cz">Orsolya Pal Cz</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Paszti Gere, Erzsebet" sort="Paszti Gere, Erzsebet" uniqKey="Paszti Gere E" first="Erzsébet" last="Pászti-Gere">Erzsébet Pászti-Gere</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Galfi, Peter" sort="Galfi, Peter" uniqKey="Galfi P" first="Péter" last="Gálfi">Péter Gálfi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István utca 2, Budapest 1078</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The <italic>in vitro</italic> anti-inflammatory effect of apigenin and its trimethylated analogue (apigenin-trimethylether) has been investigated in order to evaluate whether these flavonoids could attenuate LPS-induced inflammation in IPEC-J2 non-transformed intestinal epithelial cells. Levels of IL-6, IL-8, TNF-<italic>α</italic>, and COX-2 mRNA were measured as a marker of inflammatory response. The extracellular H<sub>2</sub>O<sub>2</sub> level in IPEC-J2 cells was also monitored by Amplex Red assay. Our data revealed that both compounds had significant lowering effect on the inflammatory response. Apigenin (at 25 <italic>μ</italic>M) significantly decreased gene expression of IL-6 in LPS-treated cells, while apigenin-trimethylether in the same concentration did not influence IL-6 mRNA level. Both apigenin and apigenin-trimethylether reduced IL-8 gene expression significantly. TNF-<italic>α</italic> mRNA level was decreased by apigenin-trimethylether, which was not influenced by apigenin. Treatment with both flavonoids caused significant reduction in the mRNA level of COX-2, but the anti-inflammatory effect of the methylated analogue was more effective than the unmethylated one. Furthermore, both flavonoids reduced significantly the level of extracellular H<sub>2</sub>O<sub>2</sub> compared to the control cells. In conclusion, the methylated apigenin analogue could avoid LPS-induced intestinal inflammation and it could be applied in the future as an effective anti-inflammatory compound.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bisht, K" uniqKey="Bisht K">K. Bisht</name></author><author><name sortKey="Wagner, K H" uniqKey="Wagner K">K.-H. Wagner</name></author><author><name sortKey="Bulmer, A C" uniqKey="Bulmer A">A. C. Bulmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, R J" uniqKey="Williams R">R. J. Williams</name></author><author><name sortKey="Spencer, J P E" uniqKey="Spencer J">J. P. E. Spencer</name></author><author><name sortKey="Rice Evans, C" uniqKey="Rice Evans C">C. 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Lo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Farkas, Orsolya" sort="Farkas, Orsolya" uniqKey="Farkas O" first="Orsolya" last="Farkas">Orsolya Farkas</name></region><name sortKey="Galfi, Peter" sort="Galfi, Peter" uniqKey="Galfi P" first="Péter" last="Gálfi">Péter Gálfi</name><name sortKey="Pal Cz, Orsolya" sort="Pal Cz, Orsolya" uniqKey="Pal Cz O" first="Orsolya" last="Pal Cz">Orsolya Pal Cz</name><name sortKey="Paszti Gere, Erzsebet" sort="Paszti Gere, Erzsebet" uniqKey="Paszti Gere E" first="Erzsébet" last="Pászti-Gere">Erzsébet Pászti-Gere</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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